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POLARITY

Epithelial polarity limits EMT

Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

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The authors declare no competing interests.

Correspondence to Carien M. Niessen.

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Fig. 1: Epithelial architecture status as a checkpoint for EMT.