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Dynamics of mRNA entry into stress granules

Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

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Fig. 1: A model for mRNA entry into stress granules.

References

  1. Fay, M. M. & Anderson, P. J. J. Mol. Biol. 430, 4685–4701 (2018).

    Article  CAS  Google Scholar 

  2. Khong, A. et al. Mol. Cell 68, 808–820 (2017).

    Article  CAS  Google Scholar 

  3. Moon, S. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0263-4 (2019).

    Article  PubMed  Google Scholar 

  4. Van Treeck, B. & Parker, R. Cell 174, 791–802 (2018).

    Article  Google Scholar 

  5. Langdon, E. M. et al. Science 360, 922–927 (2018).

    Article  CAS  Google Scholar 

  6. Khong, A. & Parker, R. J. Cell Biol. 217, 4124–4140 (2018).

    Article  Google Scholar 

  7. Adivarahan, S. et al. Mol. Cell 72, 727–738e5 (2018).

    Article  CAS  Google Scholar 

  8. Bley, N. et al. Nucleic Acid. Res. 43, e26 (2015).

    Article  Google Scholar 

  9. Aizer, A. et al. J. Cell. Sci. 127, 4443–4456 (2014).

    Article  CAS  Google Scholar 

  10. Trcek, T. et al. Nat. Commun. 6, 7962 (2015).

    Article  CAS  Google Scholar 

  11. Eagle, W. V. I., Yeboah-Kordieh, D. K., Niepielko, M. G. & Gavis, E. R. Development 145, dev164657 (2018).

    Article  Google Scholar 

  12. Jain, S. et al. Cell 164, 487–498 (2016).

    Article  CAS  Google Scholar 

  13. Nott, T. J., Craggs, T. D. & Baldwin, A. J. Nat. Chem. 8, 569–575 (2016).

    Article  CAS  Google Scholar 

  14. Dobra, I. et al. Curr. Neurol. Neurosci. Rep. 18, 107 (2018).

    Article  Google Scholar 

  15. Pichon, X., Lagha, M., Mueller, F. & Bertrand, E. Mol. Cell 71, 468–480 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Geraldine Seydoux.

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Lee, CY., Seydoux, G. Dynamics of mRNA entry into stress granules. Nat Cell Biol 21, 116–117 (2019). https://doi.org/10.1038/s41556-019-0278-5

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