Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Fay, M. M. & Anderson, P. J. J. Mol. Biol. 430, 4685–4701 (2018).
Khong, A. et al. Mol. Cell 68, 808–820 (2017).
Moon, S. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0263-4 (2019).
Van Treeck, B. & Parker, R. Cell 174, 791–802 (2018).
Langdon, E. M. et al. Science 360, 922–927 (2018).
Khong, A. & Parker, R. J. Cell Biol. 217, 4124–4140 (2018).
Adivarahan, S. et al. Mol. Cell 72, 727–738e5 (2018).
Bley, N. et al. Nucleic Acid. Res. 43, e26 (2015).
Aizer, A. et al. J. Cell. Sci. 127, 4443–4456 (2014).
Trcek, T. et al. Nat. Commun. 6, 7962 (2015).
Eagle, W. V. I., Yeboah-Kordieh, D. K., Niepielko, M. G. & Gavis, E. R. Development 145, dev164657 (2018).
Jain, S. et al. Cell 164, 487–498 (2016).
Nott, T. J., Craggs, T. D. & Baldwin, A. J. Nat. Chem. 8, 569–575 (2016).
Dobra, I. et al. Curr. Neurol. Neurosci. Rep. 18, 107 (2018).
Pichon, X., Lagha, M., Mueller, F. & Bertrand, E. Mol. Cell 71, 468–480 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lee, CY., Seydoux, G. Dynamics of mRNA entry into stress granules. Nat Cell Biol 21, 116–117 (2019). https://doi.org/10.1038/s41556-019-0278-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-019-0278-5
This article is cited by
-
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Nature Medicine (2020)