It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.
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References
Shapiro, C. L. & Recht, A. New Engl. J. Med. 344, 1997–2008 (2001).
Early Breast Cancer Trialists’ Collaborative, G. Lancet Oncol. 19, 27–39 (2018).
Pantel, K. et al. J. Natl Cancer Inst. 85, 1419–1424 (1993).
Braun, S. et al. J. Clin. Oncol. 18, 80–86 (2000).
Carlson, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0267-0 (2019).
Werner-Klein, M. et al. Nat. Commun. 9, 595 (2018).
Hosseini, H. et al. Nature 540, 552–558 (2016).
Spencer, J. A. et al. Nature 508, 269–273 (2014).
Fluegen, G. et al. Nat. Cell Biol. 19, 120–132 (2017).
Sosa, M. S. et al. Nat. Commun. 6, 6170 (2015).
Joyce, J. A. & Pollard, J. W. Nat. Rev. Cancer 9, 239–252 (2009).
Holohan, C., Van Schaeybroeck, S., Longley, D. B. & Johnston, P. G. Nat. Rev. Cancer 13, 714–726 (2013).
Minchinton, A. I. & Tannock, I. F. Nat. Rev. Cancer 6, 583–592 (2006).
Croucher, P. I., McDonald, M. M. & Martin, T. J. Nat. Rev. Cancer 16, 373–386 (2016).
Chuang, H. N. et al. Glia 61, 1331–1346 (2013).
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Werner-Klein, M., Klein, C.A. Therapy resistance beyond cellular dormancy. Nat Cell Biol 21, 117–119 (2019). https://doi.org/10.1038/s41556-019-0276-7
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DOI: https://doi.org/10.1038/s41556-019-0276-7
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