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Oncogenic AKTivation by methylation

AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.

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References

  1. 1.

    Manning, B. D. & Toker, A. Cell 169, 381–405 (2017).

  2. 2.

    Chan, C. H. et al. Cell Biosci. 4, 59 (2014).

  3. 3.

    Wang, G. H. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0266-1 (2019).

  4. 4.

    Guo, J. P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0261-6 (2019).

  5. 5.

    Yoshioka, Y. et al. Oncotarget 7, 75023–75037 (2016).

  6. 6.

    Biggar, K. K. & Li, S. S. Nat. Rev. Mol. Cell Biol. 16, 5–17 (2015).

  7. 7.

    Fei, Q. et al. Nat. Commun. 6, 8651 (2015).

  8. 8.

    Karanth, A. V. et al. Expert Opin. Ther. Targets 21, 319–331 (2017).

  9. 9.

    Berry, W. L., Shin, S., Lightfoot, S. A. & Janknecht, R. Int. J. Oncol. 41, 1701–1706 (2012).

  10. 10.

    Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F. & Birnbaum, M. J. J. Biol. Chem. 276, 38349–38352 (2001).

  11. 11.

    Chen, W. S. et al. Gene. Dev. 15, 2203–2208 (2001).

  12. 12.

    Akimov, V. et al. Nat. Struct. Mol. Biol. 25, 631–640 (2018).

  13. 13.

    Miller, R. A. et al. Aging Cell 4, 119–125 (2005).

  14. 14.

    Orentreich, N., Matias, J. R., DeFelice, A. & Zimmerman, J. A. J. Nutr. 123, 269–274 (1993).

  15. 15.

    Gu, X. et al. Science 358, 813–818 (2017).

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The authors declare no competing interests.

Correspondence to David A. Guertin.

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Fig. 1: Methylation stimulates AKT activation.