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Oncogenic AKTivation by methylation

Nature Cell Biology volume 21, pages 114–115 (2019)Cite this article

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AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.

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Fig. 1: Methylation stimulates AKT activation.

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Authors and Affiliations

  1. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    Amelia K. Luciano & David A. Guertin

  2. Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA

    David A. Guertin

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  1. Amelia K. Luciano
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  2. David A. Guertin
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Correspondence to David A. Guertin.

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The authors declare no competing interests.

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Luciano, A.K., Guertin, D.A. Oncogenic AKTivation by methylation. Nat Cell Biol 21, 114–115 (2019). https://doi.org/10.1038/s41556-019-0275-8

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