Retraction | Published:

Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing

Nature Cell Biologyvolume 21page410 (2019) | Download Citation


Retraction of: Nature Cell Biology, published online 27 July 2015.

We, the authors, are retracting this Article due to issues that have come to our attention regarding data availability, data description and figure assembly. Specifically, original numerical data are not available for the majority of the graphs presented in the paper. Although original data were available for most EMSA and immunoblot experiments, those corresponding to the published EMSA data of Supplementary Fig. 8a, the independent replicate immunoblots of Fig. 8b and Supplementary Fig. 1e, and the independent replicate EMSA data of Supplementary Figs 6e, 8b, 8c and 8d, are unavailable. Mistakes were detected in the presentation of Figs 3c, 4i and Supplementary Figs 6a, 8a, 8d, 9, and in some cases the β-actin immunoblots were erroneously described in the figure legends as loading controls, rather than as sample processing controls that were run on separate gels. Although we, the authors, believe that the key findings of the paper are still valid, given the issues with data availability we have concluded that the most appropriate course of action is to retract the Article. We deeply regret these errors and apologize to the scientific community for any confusion this publication may have caused. All authors agree with the retraction.

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Author notes

  1. These authors contributed equally: Clara Soria-Valles, Fernando G. Osorio.


  1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain

    • Clara Soria-Valles
    • , Fernando G. Osorio
    • , Ana Gutiérrez-Fernández
    • , José M. P. Freije
    •  & Carlos López-Otín
  2. Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    • Alejandro De Los Angeles
    •  & George Q. Daley
  3. Josep Carreras Leukemia Research Institute, Cell Therapy Program of the University of Barcelona, Faculty of Medicine, 08036, Barcelona, Spain

    • Clara Bueno
    •  & Pablo Menéndez
  4. Institucio Catalana de Recerca i Estudis Avançats (ICREA), 08035, Barcelona, Spain

    • Pablo Menéndez
  5. Departamento de Anatomía Patológica, Farmacología y Microbiología, Universitat de Barcelona, IDIBAPS, 08036, Barcelona, Spain

    • José I. Martín-Subero
  6. Howard Hughes Medical Institute, Boston, Massachusetts, 02115, USA

    • George Q. Daley
  7. Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, 02138, USA

    • George Q. Daley


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Corresponding authors

Correspondence to José M. P. Freije or Carlos López-Otín.

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