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EPIGENETICS

Memory of ancestral mitochondrial stress

Nature Cell Biology volume 21, pages 303–304 (2019)Cite this article

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Ancestral experience of mitochondrial stress is now found to render progeny of the roundworm Caenorhabditis elegans more resistant to the same insult for up to four generations. A DNA modification, N6-methyldeoxyadenine, is implicated in the inheritance of this stress adaptation.

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Fig. 1: Ancestral exposure to mitochondrial stress increases stress resistance trans-generationally in C. elegans.

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Authors and Affiliations

  1. Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain

    Sarah-Lena Offenburger, Marcos Francisco Perez & Ben Lehner

  2. Universitat Pompeu Fabra (UPF), Barcelona, Spain

    Ben Lehner

  3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    Ben Lehner

Authors
  1. Sarah-Lena Offenburger
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  2. Marcos Francisco Perez
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  3. Ben Lehner
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Correspondence to Ben Lehner.

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Offenburger, SL., Perez, M.F. & Lehner, B. Memory of ancestral mitochondrial stress. Nat Cell Biol 21, 303–304 (2019). https://doi.org/10.1038/s41556-018-0255-4

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