News & Views | Published:

CANCER

Targeting BAF-perturbed cancers

BAF is a heterogenous chromatin-remodelling complex, frequently mutated in cancer. A study now defines genome-wide localization patterns of three complexes, cBAF, PBAF and previously unknown ncBAF, and reveals the ncBAF complex as a specific vulnerability in synovial sarcoma and malignant rhabdoid tumours.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Wang, W. et al. Genes Dev. 10, 2117–30 (1996).

  2. 2.

    Wang, W. Curr. Topics Microbiol. Immunol. 274, 143–169 (2003).

  3. 3.

    Alpsoy, A. & Dykhuizen, E. C. J. Biol. Chem. 293, 3892–3903 (2018).

  4. 4.

    Shain, A. H. & Pollack, J. R. PLoS ONE 8, e55119 (2013).

  5. 5.

    Kadoch, C. et al. Nat. Genet. 45, 592 (2013).

  6. 6.

    Helming, K. C. et al. Nat. Med. 20, 251–254 (2014).

  7. 7.

    Wilson, B. G. et al. Mol. Cell. Biol. 34, 1136–1144 (2014).

  8. 8.

    Michel, B. C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0221-1 (2018).

  9. 9.

    Alver, B. H. et al. Nat. Commun. 8, 1–10 (2017).

  10. 10.

    Nakayama, R. T. et al. Nat. Genet. 49, 1613–1623 (2017).

  11. 11.

    Wang, X. et al. Nat. Genet. 49, 289–295 (2017).

  12. 12.

    Kadoch, C. & Crabtree, G. R. Cell 153, 71–85 (2013).

  13. 13.

    McBride, M. J. et al. Cancer Cell 33, 1128–1141 (2018).

  14. 14.

    Dutta, A. et al. Cell Rep. 18, 2124–2134 (2017).

  15. 15.

    Marshall, A. D. et al. Oncogene 36, 4100 (2017).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Jerry L. Workman.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: ncBAF is a vulnerability in SMARCB1 mutated cancers.