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CELL CYCLE

CENP-T bears the load in mitosis

During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

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References

  1. 1.

    Musacchio, A. Curr. Biol. 25, R1002–R1018 (2015).

  2. 2.

    Hara, M. & Fukagawa, T. Curr. Opin. Cell Biol. 52, 73–81 (2018).

  3. 3.

    Monda, J. K. & Cheeseman, I. M. J. Cell Sci. 131, jcs.214577 (2018).

  4. 4.

    Kim, S. & Yu, H. J. Cell Biol. 208, 181–196 (2015).

  5. 5.

    Przewloka, M. R. et al. Curr. Biol. 21, 399–405 (2011).

  6. 6.

    Screpanti, E. et al. Curr. Biol. 21, 391–398 (2011).

  7. 7.

    Hara, M., Ariyoshi, M., Okumura, E., Hori, T. & Fukagawa, T. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0230-0 (2018).

  8. 8.

    Ciferri, C. et al. Cell 133, 427–439 (2008).

  9. 9.

    Petrovic, A. et al. J. Cell Biol. 190, 835–852 (2010).

  10. 10.

    Petrovic, A. et al. Mol. Cell 53, 591–605 (2014).

  11. 11.

    Petrovic, A. et al. Cell 167, 1028–1040 e1015 (2016).

  12. 12.

    Huis In ‘t Veld, P. J. et al. eLife 5, e21007 (2016).

  13. 13.

    Malvezzi, F. et al. EMBO J. 32, 409–423 (2013).

  14. 14.

    Volkov, V. A., Huis In ‘t Veld, P. J., Dogterom, M. & Musacchio, A. eLife 7, e36764 (2018).

  15. 15.

    Lang, J., Barber, A. & Biggins, S. eLife 7, e37819 (2018).

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Correspondence to Hongtao Yu.

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Fig. 1: Phosphorylation-regulated kinetochore plasticity during mitosis.