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CLN8 safeguards lysosome biogenesis

Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

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The author declares no competing interests.

Correspondence to J. Paul Luzio.

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Fig. 1: CLN8 is an ER-export receptor for many soluble lysosomal proteins.