TBK1 and IKKε restrain cell death

RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might therapeutically benefit from RIPK1 inhibition. Recent studies now show that TBK1 and IKKε constitute a cell death checkpoint that restrains RIPK1 activation.

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Fig. 1: Multiple inhibitory phosphorylation events converge on RIPK1 to limit cell death.


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Correspondence to Vishva M. Dixit.

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Both authors are employees of Genentech.

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Heger, K., Dixit, V.M. TBK1 and IKKε restrain cell death. Nat Cell Biol 20, 1330–1331 (2018). https://doi.org/10.1038/s41556-018-0239-4

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