CELL DEATH

TBK1 and IKKε restrain cell death

RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might therapeutically benefit from RIPK1 inhibition. Recent studies now show that TBK1 and IKKε constitute a cell death checkpoint that restrains RIPK1 activation.

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Fig. 1: Multiple inhibitory phosphorylation events converge on RIPK1 to limit cell death.

References

  1. 1.

    Clark, K., Plater, L., Peggie, M. & Cohen, P. J. Biol. Chem. 284, 14136–14146 (2009).

    CAS  Article  Google Scholar 

  2. 2.

    Ahmad, L., Zhang, S.-Y., Casanova, J.-L. & Sancho-Shimizu, V. Trends Mol. Med. 22, 511–527 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Dikic, I. & Elazar, Z. Nat. Rev. Mol. Cell Biol. 19, 349–364 (2018).

  4. 4.

    Lafont, E. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0229-6 (2018).

  5. 5.

    Newton, K. Trends Cell Biol. 25, 347–353 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Peltzer, N., Darding, M. & Walczak, H. Trends Cell Biol. 26, 445–461 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Witt, A. & Vucic, D. Cell Death Differ. 24, 1160–1171 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Dondelinger, Y. et al. Mol. Cell 60, 63–76 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Dondelinger, Y. et al. Nat. Cell Biol. 19, 1237–1247 (2017).

  10. 10.

    Jaco, I. et al. Mol. Cell 66, 698–710 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Menon, M. B. et al. Nat. Cell Biol. 19, 1248–1259 (2017).

  12. 12.

    Geng, J. et al. Nat. Commun. 8, 359 (2017).

    Article  Google Scholar 

  13. 13.

    Xu, D. et al. Cell 174, 1477–1491 (2018).

    CAS  Article  Google Scholar 

  14. 14.

    Vlantis, K. et al. Immunity 44, 553–567 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Rahighi, S. et al. Cell 136, 1098–1109 (2009).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Vishva M. Dixit.

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Both authors are employees of Genentech.

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Heger, K., Dixit, V.M. TBK1 and IKKε restrain cell death. Nat Cell Biol 20, 1330–1331 (2018). https://doi.org/10.1038/s41556-018-0239-4

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