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CELL DEATH

TBK1 and IKKε restrain cell death

Nature Cell Biologyvolume 20pages13301331 (2018) | Download Citation

RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might therapeutically benefit from RIPK1 inhibition. Recent studies now show that TBK1 and IKKε constitute a cell death checkpoint that restrains RIPK1 activation.

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Author information

Affiliations

  1. Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA

    • Klaus Heger
    •  & Vishva M. Dixit

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Competing interests

Both authors are employees of Genentech.

Corresponding author

Correspondence to Vishva M. Dixit.

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DOI

https://doi.org/10.1038/s41556-018-0239-4

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