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Atypical matrix adhesions guide cell division

Classical actin-dependent, integrin-mediated cell–matrix adhesions disassemble before mitotic rounding. Yet, to transmit positional information and facilitate daughter-cell separation, dividing cells maintain connections to the matrix. A previously unidentified class of actin-independent integrin adhesions may fulfil this task.

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Fig. 1: Reticular adhesions guide cell division.


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Correspondence to Ronen Zaidel-Bar.

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Zaidel-Bar, R. Atypical matrix adhesions guide cell division. Nat Cell Biol 20, 1233–1235 (2018).

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