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CRAD as a cytoskeletal tumour suppressor

Nature Cell Biology volume 20, pages 1232–1233 (2018)Cite this article

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β-catenin regulates cell–cell adhesion and maintains stemness through Wnt signalling, but how these functions are mechanistically related is not fully understood. A study now identifies CRAD as the mechanistic link, providing insight into how dysregulation of epithelial adhesion contributes to Wnt-driven tumorigenesis.

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Fig. 1: Schematic representation of CRAD function.

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Authors and Affiliations

  1. The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

    George Eng, Jonathan Braverman & Ömer H. Yilmaz

  2. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

    George Eng & Ömer H. Yilmaz

Authors
  1. George Eng
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  2. Jonathan Braverman
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  3. Ömer H. Yilmaz
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Correspondence to Ömer H. Yilmaz.

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The authors declare no competing interests.

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Eng, G., Braverman, J. & Yilmaz, Ö.H. CRAD as a cytoskeletal tumour suppressor. Nat Cell Biol 20, 1232–1233 (2018). https://doi.org/10.1038/s41556-018-0225-x

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