The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.
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Kuri, P., Rompolas, P. Differentiation keeps skin cancer at bay. Nat Cell Biol 20, 1237–1239 (2018). https://doi.org/10.1038/s41556-018-0222-0
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DOI: https://doi.org/10.1038/s41556-018-0222-0
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Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas
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