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STEM CELLS

Differentiation keeps skin cancer at bay

The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

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Fig. 1: Oncogenic Pik3ca biases basal progenitor cell fate towards differentiation.

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Correspondence to Panteleimon Rompolas.

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Kuri, P., Rompolas, P. Differentiation keeps skin cancer at bay. Nat Cell Biol 20, 1237–1239 (2018). https://doi.org/10.1038/s41556-018-0222-0

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