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STEM CELLS

Differentiation keeps skin cancer at bay

The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

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References

  1. 1.

    Gonzales, K. A. U. & Fuchs, E. Dev. Cell 43, 387–401 (2017).

  2. 2.

    Vogelstein, B. et al. Science 339, 1546–1558 (2013).

  3. 3.

    Ying, Z., Sandoval, M. & Beronja, S. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0218-9 (2018).

  4. 4.

    Fruman, D. A. et al. Cell 170, 605–635 (2017).

  5. 5.

    Sánchez-Danés, A. & Blanpain, C. Nat. Rev. Cancer 18, 549–561 (2018).

  6. 6.

    Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J. & van Deursen, J. M. EMBO Rep. 15, 1139–1153 (2014).

  7. 7.

    Gudipaty, S. A. et al. Nature 543, 118–121 (2017).

  8. 8.

    Rompolas, P. et al. Science 352, 1471–1474 (2016).

  9. 9.

    Xu, Z., Kukekov, N. V. & Greene, L. A. EMBO J. 22, 252–261 (2003).

  10. 10.

    Lyons, T. R. et al. J. Biol. Chem. 282, 21987–21997 (2007).

  11. 11.

    Kajita, M. & Fujita, Y. J. Biochem. 158, 15–23 (2015).

  12. 12.

    Brown, S. et al. Nature 548, 334–337 (2017).

  13. 13.

    Martincorena, I. et al. Science 348, 880–886 (2015).

  14. 14.

    Rognoni, E. & Watt, F. M. Trends Cell Biol. 28, 709–722 (2018).

  15. 15.

    Spira, A. I. & Carducci, M. A. Curr. Opin. Pharmacol. 3, 338–343 (2003).

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The authors declare no competing interests.

Correspondence to Panteleimon Rompolas.

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Fig. 1: Oncogenic Pik3ca biases basal progenitor cell fate towards differentiation.