Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.
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J.J. was supported by the British Society for Immunology; H.Z. by Mayo Foundation Center for Clinical and Translational Science (CCATS) and Lupus Link Minnesota; and T.H. by NIH grant R01AI102964.
The authors declare no competing interests.
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Jung, J., Zeng, H. & Horng, T. Metabolism as a guiding force for immunity. Nat Cell Biol 21, 85–93 (2019). https://doi.org/10.1038/s41556-018-0217-x
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