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Microenvironmental cues in cancer stemness

Intra-tumour heterogeneity manifests both at the level of mutational burden, and at a functional level within genetically homogenous populations. A new modelling approach suggests stemness within colorectal tumours is defined by microenvironmental cues secreted from cancer-associated fibroblasts rather than cell-intrinsic properties.

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Author information

Flanagan, D. J. and Hodder, M. C. contributed equally.

Competing interests

The authors declare no competing interests.

Correspondence to O. J. Sansom.

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Fig. 1: Cancer stem cells drive CRC expansion from the tumour edge.