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Metabolic control of ferroptosis in cancer

Nature Cell Biologyvolume 20pages11041105 (2018) | Download Citation

Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

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References

  1. 1.

    Anderson, C. P. et al. Biochim. Biophys. Acta 1823, 1468–1483 (2012).

  2. 2.

    Halliwell, B. H. & Gutteridge, J. M. C. Free radicals in Biology and Medicine. 5th ed, (Oxford Univ. Press, Oxford, 2015).

  3. 3.

    Stockwell, B. R. et al. Cell 171, 273–285 (2017).

  4. 4.

    Yang, W. S. & Stockwell, B. R. Trends Cell Biol 26, 165–176 (2016).

  5. 5.

    Zhang, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0178-0 (2018).

  6. 6.

    Rai, K., Pilarski, R., Cebulla, C. M. & Abdel-Rahman, M. H. Clin. Genet. 89, 285–294 (2016).

  7. 7.

    Jensen, D. E. et al. Oncogene 16, 1097–1112 (1998).

  8. 8.

    Jiang, L. et al. Nature 520, 57–62 (2015).

  9. 9.

    Koppula, P., Zhang, Y., Zhuang, L. & Gan, B. Cancer Commun. 38, 12 (2018).

  10. 10.

    Yang, W. S. et al. Cell 156, 317–331 (2014).

  11. 11.

    Yang, Y. et al. J. Biol. Chem. 276, 19220–19230 (2001).

  12. 12.

    Dolma, S., Lessnick, S. L., Hahn, W. C. & Stockwell, B. R. Cancer Cell 3, 285–296 (2003).

  13. 13.

    Portt, L. et al. Biochim. Biophys. Acta 1813, 238–259 (2011).

Download references

Author information

Affiliations

  1. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    • Michael P. Murphy

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Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Michael P. Murphy.

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DOI

https://doi.org/10.1038/s41556-018-0209-x

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