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A mitochondria–paraspeckle crosstalk

Paraspeckles are nuclear bodies built on the long noncoding RNA, NEAT1, that regulate cellular homeostasis, but how they sense and help under stress is unclear. A study now shows mitochondrial stress modulates paraspeckles by altering NEAT1 expression with a feedback loop that influences mitochondrial homeostasis.

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Fig. 1: Mechanism underlying mitochondria–paraspeckle crosstalk.


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Correspondence to Archa H. Fox.

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Fox, A.H. A mitochondria–paraspeckle crosstalk. Nat Cell Biol 20, 1108–1109 (2018).

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