Turning back time with emerging rejuvenation strategies

Abstract

Ageing is associated with the functional decline of all tissues and a striking increase in many diseases. Although ageing has long been considered a one-way street, strategies to delay and potentially even reverse the ageing process have recently been developed. Here, we review four emerging rejuvenation strategies—systemic factors, metabolic manipulations, senescent cell ablation and cellular reprogramming—and discuss their mechanisms of action, cellular targets, potential trade-offs and application to human ageing.

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Fig. 1: Comparison of emerging strategies for organismal rejuvenation and lifespan.
Fig. 2: Potential common mechanisms and target cells of the rejuvenation strategies.

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Acknowledgements

We apologize to those colleagues whose work we could not cite owing to space limitations. We thank C. Kenyon, P. Singh, J. Vos, M. Quarta and A. Colville for helpful feedback on the manuscript. This work was supported by the Stanford Graduate Fellowship (L.X.) and a generous philanthropic gift from M. Barakett and T. Barakett.

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Supplementary Table 1

Extended summary of studies testing rejuvenation interventions at midlife and later in wild type mice.

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Mahmoudi, S., Xu, L. & Brunet, A. Turning back time with emerging rejuvenation strategies. Nat Cell Biol 21, 32–43 (2019). https://doi.org/10.1038/s41556-018-0206-0

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