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Lysosomal catch-and-release controls mTORC1

Nature Cell Biology volume 20, pages 996–997 (2018)Cite this article

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Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

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Fig. 1: A nutrient-sensitive catch-and-release mechanism regulates mTORC1 localization to the lysosome.

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Authors and Affiliations

  1. Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA

    Aaron M. Hosios & Brendan D. Manning

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  1. Aaron M. Hosios
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  2. Brendan D. Manning
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Correspondence to Brendan D. Manning.

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The authors declare no competing interests.

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Hosios, A.M., Manning, B.D. Lysosomal catch-and-release controls mTORC1. Nat Cell Biol 20, 996–997 (2018). https://doi.org/10.1038/s41556-018-0188-y

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