METABOLISM

Mechanical signals regulate TORC2 activity

Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

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Fig. 1: A mechanotransduction pathway for regulating TORC2 activity.

References

  1. 1.

    Anitei, M. & Hoflack, B. Nat. Cell Biol. 14, 11–19 (2011).

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Pontes, B., Monzo, P. & Gauthier, N. C. Semin. Cell Dev. Biol. 71, 30–41 (2017).

    Article  PubMed  CAS  Google Scholar 

  3. 3.

    Riggi, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0150-z (2018).

  4. 4.

    Gaubitz, C., Prouteau, M., Kusmider, B. & Loewith, R. Trends Biochem. Sci. 41, 532–545 (2016).

    Article  PubMed  CAS  Google Scholar 

  5. 5.

    Saxton, R. A. & Sabatini, D. M. Cell 169, 361–371 (2017).

    Article  PubMed  CAS  Google Scholar 

  6. 6.

    Berchtold, D. et al. Nat. Cell Biol. 14, 542–547 (2012).

    Article  PubMed  CAS  Google Scholar 

  7. 7.

    Walther, T. C. et al. Nature 439, 998–1003 (2006).

    Article  PubMed  CAS  Google Scholar 

  8. 8.

    Singer-Kruger, B., Nemoto, Y., Daniell, L., Ferro-Novick, S. & De Camilli, P. J. Cell Sci. 111, 3347–3356 (1998).

    PubMed  CAS  Google Scholar 

  9. 9.

    Tsujita, K., Takenawa, T. & Itoh, T. Nat. Cell Biol. 17, 749–758 (2015).

    Article  PubMed  CAS  Google Scholar 

  10. 10.

    Berchtold, D. & Walther, T. C. Mol. Biol. Cell 20, 1565–1575 (2009).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. 11.

    Karuppasamy, M. et al. Nat. Commun. 8, 1729 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. 12.

    Prouteau, M. et al. Nature 550, 265–269 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. 13.

    Wippich, F. et al. Cell 152, 791–805 (2013).

    Article  PubMed  CAS  Google Scholar 

  14. 14.

    Sedding, D. G. et al. Circ. Res. 96, 635–642 (2005).

    Article  PubMed  CAS  Google Scholar 

  15. 15.

    Hagiwara, A. et al. Cell Metab. 15, 725–738 (2012).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Volker Haucke.

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Ebner, M., Haucke, V. Mechanical signals regulate TORC2 activity. Nat Cell Biol 20, 994–995 (2018). https://doi.org/10.1038/s41556-018-0181-5

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