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METABOLISM

Mechanical signals regulate TORC2 activity

Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

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The authors declare no competing interests.

Correspondence to Volker Haucke.

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Fig. 1: A mechanotransduction pathway for regulating TORC2 activity.