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METABOLISM

Mechanical signals regulate TORC2 activity

Nature Cell Biology volume 20, pages 994–995 (2018)Cite this article

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Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

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Fig. 1: A mechanotransduction pathway for regulating TORC2 activity.

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Authors and Affiliations

  1. Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

    Michael Ebner & Volker Haucke

  2. Faculty of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany

    Volker Haucke

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  1. Michael Ebner
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  2. Volker Haucke
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Correspondence to Volker Haucke.

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The authors declare no competing interests.

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Ebner, M., Haucke, V. Mechanical signals regulate TORC2 activity. Nat Cell Biol 20, 994–995 (2018). https://doi.org/10.1038/s41556-018-0181-5

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