CANCER

The mechanics of metastatic seeding

Metastatic colonization of distant organs is the prime cause of mortality from cancer, and is governed by a series of steps that include survival and growth in the perivascular niche. A study now shows that L1CAM is necessary for tight physical interactions in this niche, involving a YAP–MRTF–β1-integrin mechanotransduction pathway.

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Fig. 1: Survival and proliferation of metastatic tumour cells in the perivascular niche depends on L1CAM–ILK–YAP mechanotransduction signalling.

References

  1. 1.

    Husemann, Y. et al. Cancer Cell 13, 58–68 (2008).

  2. 2.

    Er, E. E. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0138-8 (2018).

  3. 3.

    Winkler, F. J. Pathol. 242, 267–272 (2017).

  4. 4.

    Ghajar, C. M. et al. Nat. Cell Biol. 15, 807–817 (2013).

  5. 5.

    Kienast, Y. et al. Nat. Med. 16, 116–122 (2010).

  6. 6.

    Valiente, M. et al. Cell 156, 1002–1016 (2014).

  7. 7.

    Kim, T. et al. EMBO J. 36, 520–535 (2017).

  8. 8.

    Medjkane, S. et al. Nat. Cell Biol. 11, 257–268 (2009).

  9. 9.

    Shenoy, A. K. et al. J. Clin. Investig. 126, 4174–4186 (2016).

  10. 10.

    Armulik, A. et al. Nature 468, 557–561 (2010).

  11. 11.

    Carbonell, W. S., Ansorge, O., Sibson, N. & Muschel, R. PLoS ONE 4, e5857 (2009).

  12. 12.

    Wei, S. C. et al. Nat. Cell Biol. 17, 678–688 (2015).

  13. 13.

    Liu, L. et al. Sci. Transl. Med. 9, eaan2966 (2017).

  14. 14.

    Murgai, M. et al. Nat. Med. 23, 1176–1190 (2017).

  15. 15.

    Osswald, M. et al. Nature 528, 93–98 (2015).

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Correspondence to Frank Winkler.

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Karreman, M.A., Winkler, F. The mechanics of metastatic seeding. Nat Cell Biol 20, 860–862 (2018). https://doi.org/10.1038/s41556-018-0162-8

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