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DNA repair

Assembling a protective shield

Nature Cell Biologyvolume 20pages862863 (2018) | Download Citation

A previously unidentified protein complex termed Shieldin acts with the nucleosome-binding protein 53BP1 to limit end resection at DNA double-strand breaks, impacting myriad biological outcomes, from immunology to cancer therapy, and highlighting the importance of chromatin responses to DNA damage in vertebrates.

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Affiliations

  1. Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    • Roger A Greenberg

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  1. Search for Roger A Greenberg in:

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The author declares no competing interests.

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Correspondence to Roger A Greenberg.

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https://doi.org/10.1038/s41556-018-0152-x

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