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Grasping for aspartate in tumour metabolism

The metabolic phenotype of tumours is shaped by a complex interplay between cancer cells and their microenvironment. Two studies now show that aspartate acquisition is a metabolic limitation encountered by certain tumours in their native in vivo environment, and that overcoming this limitation is advantageous for tumour growth.

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Fig. 1: Schematic summary of strategies used by Sullivan et al. and Garcia-Bermudez et al. to overcome limitations in aspartate acquisition in tumours.


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Correspondence to Nika N. Danial.

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Fu, A., Danial, N.N. Grasping for aspartate in tumour metabolism. Nat Cell Biol 20, 738–739 (2018).

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