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Grasping for aspartate in tumour metabolism

The metabolic phenotype of tumours is shaped by a complex interplay between cancer cells and their microenvironment. Two studies now show that aspartate acquisition is a metabolic limitation encountered by certain tumours in their native in vivo environment, and that overcoming this limitation is advantageous for tumour growth.

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Fig. 1: Schematic summary of strategies used by Sullivan et al. and Garcia-Bermudez et al. to overcome limitations in aspartate acquisition in tumours.

References

  1. 1.

    Lyssiotis, C. A. & Kimmelman, A. C. Trends Cell Biol. 27, 863–875 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Vander Heiden, M. G. & DeBerardinis, R. J. Cell 168, 657–669 (2017).

    Article  Google Scholar 

  3. 3.

    Garcia-Bermudez, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0118-z (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Sullivan, L. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0125-z (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Birsoy, K. et al. Cell 162, 540–551 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Sullivan, L. B. et al. Cell 162, 552–563 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Mayers, J. R. & Vander Heiden, M. G. Trends Biochem. Sci. 40, 130–140 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Krall, A. S., Xu, S., Graeber, T. G., Braas, D. & Christofk, H. R. Nat. Commun. 7, 11457 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Zhang, J. et al. Mol. Cell 56, 205–218 (2014).

    CAS  Article  Google Scholar 

  10. 10.

    Gui, D. Y. et al. Cell Metab. 24, 716–727 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Rabinovich, S. et al. Nature 527, 379–383 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Commisso, C. et al. Nature 497, 633–637 (2013).

    CAS  Article  Google Scholar 

  13. 13.

    Davidson, S. M. et al. Nat. Med. 23, 235–241 (2017).

    CAS  Article  Google Scholar 

  14. 14.

    Cardaci, S. et al. Nat. Cell Biol. 17, 1317–1326 (2015).

    CAS  Article  Google Scholar 

  15. 15.

    Sellers, K. et al. J. Clin. Invest. 125, 687–698 (2015).

    Article  Google Scholar 

Download references

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Correspondence to Nika N. Danial.

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Fu, A., Danial, N.N. Grasping for aspartate in tumour metabolism. Nat Cell Biol 20, 738–739 (2018). https://doi.org/10.1038/s41556-018-0137-9

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