EMBRYOGENESIS

A single-cell chromatin map of human embryos

The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Overview of global chromatin accessibility dynamics and variance during human preimplantation development.

References

  1. 1.

    Eckersley-Maslin, M. A., Alda-Catalinas, C. & Reik, W. Nat. Rev. Mol. Cell Biol. http://doi.org/cqfn (2018).

  2. 2.

    Kelsey, G., Stegle, O. & Reik, W. Science 358, 69–75 (2017).

  3. 3.

    Zhu, P. et al. Nat. Genet. 50, 12–19 (2018).

  4. 4.

    Yan, L. et al. Nat. Struct. Mol. Biol. 20, 1131–1139 (2013).

  5. 5.

    Xue, Z. et al. Nature 500, 593–597 (2013).

  6. 6.

    Gao, L. et al. Cell 173, 248–259 (2018).

  7. 7.

    Wu, J. et al. Nature 557, 256–260 (2018).

  8. 8.

    Li, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0123-2 (2018).

  9. 9.

    Guo, F. et al. Cell Res. 27, 967–988 (2017).

  10. 10.

    Veselovska, L. et al. Genome Biol. 16, 209 (2015).

  11. 11.

    Wu, J. et al. Nature 534, 652–657 (2016).

  12. 12.

    Goolam, M. et al. Cell 165, 61–74 (2016).

  13. 13.

    Xu, Q. & Xie, W. Trends Cell Biol. 28, 237–253 (2018).

  14. 14.

    Clark, S. J. et al. Nat. Commun. 9, 781 (2018).

  15. 15.

    Hainer, S. J., Boskovic, A., Rando, O. J. & Fazzio, T. G. bioRxiv http://doi.org/cqfp (2018).

Download references

Author information

Correspondence to Deborah Bourc’his.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark