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A single-cell chromatin map of human embryos

The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.

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Fig. 1: Overview of global chromatin accessibility dynamics and variance during human preimplantation development.


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Correspondence to Deborah Bourc’his.

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The authors declare no competing interests.

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Pérez-Palacios, R., Bourc’his, D. A single-cell chromatin map of human embryos. Nat Cell Biol 20, 742–744 (2018).

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