The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Eckersley-Maslin, M. A., Alda-Catalinas, C. & Reik, W. Nat. Rev. Mol. Cell Biol. http://doi.org/cqfn (2018).
Kelsey, G., Stegle, O. & Reik, W. Science 358, 69–75 (2017).
Zhu, P. et al. Nat. Genet. 50, 12–19 (2018).
Yan, L. et al. Nat. Struct. Mol. Biol. 20, 1131–1139 (2013).
Xue, Z. et al. Nature 500, 593–597 (2013).
Gao, L. et al. Cell 173, 248–259 (2018).
Wu, J. et al. Nature 557, 256–260 (2018).
Li, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0123-2 (2018).
Guo, F. et al. Cell Res. 27, 967–988 (2017).
Veselovska, L. et al. Genome Biol. 16, 209 (2015).
Wu, J. et al. Nature 534, 652–657 (2016).
Goolam, M. et al. Cell 165, 61–74 (2016).
Xu, Q. & Xie, W. Trends Cell Biol. 28, 237–253 (2018).
Clark, S. J. et al. Nat. Commun. 9, 781 (2018).
Hainer, S. J., Boskovic, A., Rando, O. J. & Fazzio, T. G. bioRxiv http://doi.org/cqfp (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Pérez-Palacios, R., Bourc’his, D. A single-cell chromatin map of human embryos. Nat Cell Biol 20, 742–744 (2018). https://doi.org/10.1038/s41556-018-0134-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-018-0134-z