Mitochondria sense and respond to many stressors and can support cell survival or death through energy production and signalling pathways. Mitochondrial responses depend on fusion–fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, such as with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.
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Acknowledgements
We thank David Weaver and Orian Shirihai for comments. This work was supported by FONDECYT 1150677 to VE, the Wharton Fund, NIH-R35-GM119793 and R21-MH113011 to MP, and R01-DK51526, R33-ES025672 and UO1-AA021122 to GH.
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Eisner, V., Picard, M. & Hajnóczky, G. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses. Nat Cell Biol 20, 755–765 (2018). https://doi.org/10.1038/s41556-018-0133-0
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DOI: https://doi.org/10.1038/s41556-018-0133-0
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