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Pro-tumorigenic AMPK in glioblastoma

AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.

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Fig. 1: Adaptive pathways mediated by AMPK in normal/resting, normal/stressed and malignant cells.

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Correspondence to Constantinos Koumenis.

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Leli, N.M., Koumenis, C. Pro-tumorigenic AMPK in glioblastoma. Nat Cell Biol 20, 736–737 (2018). https://doi.org/10.1038/s41556-018-0129-9

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