Comment | Published:

Consent for governance in the ethical use of organoids

Nature Cell Biologyvolume 20pages642645 (2018) | Download Citation

Subjects

Current advances in biotechnology open up unprecedented possibilities to transform human tissues into complex, valuable tissue products, such as organoids. Here, we propose consent for governance as a leading paradigm for the derivation, storage and use of complex human tissue products to ensure adjustment to changing ethical requirements.

  • Subscribe to Nature Cell Biology for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    Aach, J., Lunshof, J., Iyer, E. & Church, G. eLife 21, e20674 (2017).

  2. 2.

    Bredenoord, A. L. & Hyun, I. EMBO Mol. Med. 9, 396–398 (2017).

  3. 3.

    Munsie, M., Hyun, I. & Sugarman, J. Development 144, 942–5 (2017).

  4. 4.

    Bredenoord, A. L., Clevers, H. & Knoblich, J. A. Science 355, eaaf9414 (2017).

  5. 5.

    Bartfeld, S. & Clevers, H. J. Mol. Med. 95, 729–738 (2017).

  6. 6.

    Lancaster, M. A. & Knoblich, J. A. Science 345, 1247125 (2014).

  7. 7.

    Mostert, M., Bredenoord, A. L., Biesaart, M. C. I. H. & van Delden, J. J. M. Eur. J. Hum. Genet. 24, 956–960 (2016).

  8. 8.

    Burningham, S., Ollenberger, A. & Caulfiled, T. Stem Cells Dev. 22, 80–84 (2013).

  9. 9.

    Waldby, C. & Mitchell, R. Tissue Economies: Blood Organs and Cell Lines in Late Capitalism (Duke University Press, London, 2006).

  10. 10.

    Hyun, I. Cell Stem Cell 21, 718–720 (2018).

  11. 11.

    Saini, A. Cell Stem Cell 19, 425–427 (2016).

  12. 12.

    Aalto-Setälä, K., Conklin, B. R. & Lo, B. PLoS Biol. 7, e1000042 (2009).

  13. 13.

    Lowenthal, J., Lipnick, S., Rao, M. & Hull, S. C. Stem Cells Transl. Med. 1, 409–421 (2012).

  14. 14.

    Boers, S. N., van Delden, J. J., Clevers, H. & Bredenoord, A. L. EMBO Rep. 17, 938–941 (2016).

  15. 15.

    Grady, C. et al. Am. J. Bioeth. 15, 34–42 (2015).

  16. 16.

    Kaye, J. et al. Eur. J. Hum. Genet. 23, 141–146 (2015).

  17. 17.

    Chalmers, D. et al. Pub. Health Ethics 8, 63–71 (2015).

  18. 18.

    Ram, N. Jurimetr. J. 48, 253–284 (2008).

  19. 19.

    Boers, S. N., van Delden, J. J. M. & Bredenoord, A. L. Am. J. Bioeth. 15, 53–55 (2015).

  20. 20.

    Huch, M. et al. Cell 160, 299–312 (2015).

  21. 21.

    Dekkers, J. F. et al. Sci. Transl. Med. 8, 344ra84 (2016).

  22. 22.

    Boers, S. N. et al. J. Cyst. Fibros. http://doi.org/cnw6 (2018).

  23. 23.

    Lavazza, A. & Massimini, M. J. Med. Ethics http://doi.org/gc4dfp (2018).

  24. 24.

    Lancaster, M. A. et al. Nature 501, 373–379 (2013).

  25. 25.

    Galapagos Licenses Organoid Technology from the HUB Foundation for Use in Cystic Fibrosis and IBD Research (Hubrecht Organoid Technology, 2015).

  26. 26.

    Smadar, C. Nat. Biotechnol. 34, 619 (2016).

  27. 27.

    Chakradhar, S. Nat. Med. 22, 338–338 (2016).

  28. 28.

    Critchley, C. R., Bruce, G. & Farrugia, M. Stem Cell Rev. 9, 541–554 (2013).

  29. 29.

    Caulfield, T. & Kaye, J. Med. Law Int. 10, 85–100 (2009).

  30. 30.

    Eriksson, S. & Helgesson, G. Eur. J. Hum. Genet. 13, 1071–1076 (2015).

  31. 31.

    General Data Protection Regulation (GDPR) Article 25: Data Protection by Design and by Default (European Parliament & European Council, 2016).

  32. 32.

    Gottweis, H., Gaskell, G. & Starkbaum, J. Nat. Rev. Genet. 12, 738–739 (2011).

  33. 33.

    Boeckhout, M., Reuzel, R. & Zielhuis, G. The Donor as Partner: How to Involve Patients and the Public in the Governance of Biobanks and Registries (Biobanking and Biomolecular Research Infrastructure–the Netherlands, 2014).

  34. 34.

    Nicol, D. J. Int. Biotechnol. Law 3, 89–103 (2006).

  35. 35.

    Knoppers, B. M. et al. Community Genet. 3, 88–92 (2000).

  36. 36.

    Dauda, B. & Dierickx, K. BMC Med. Ethics 14, 36 (2013).

  37. 37.

    Commission Recommendation of 17.7.2012 on access to and preservation of scientific information (European Commission, 2012)

  38. 38.

    Johnston, J. & Wasunna, A. A. Hastings Cent. Rep. 37, 31–36 (2007).

  39. 39.

    Guerrini, C. J., Curnutte, M. A., Sherkow, J. S. & Scott, C. T. Nat. Biotechnol. 35, 22–24 (2017).

  40. 40.

    Guidelines for Stem Cell Research and Clinical Translation (International Society for Stem Cell Research, 2016)

  41. 41.

    Giesbertz, N. A. A., Bredenoord, A. L. & van Delden, J. J. M. PLoS Biol. 10, e1001373 (2012).

Download references

Acknowledgements

We acknowledge Jeffrey Beekman, department of Pediatric Pulmonology, Wilhelmina Children’s Hospital and the Regenerative Medicine Center Utrecht, the Netherlands, and J.J.M. van Delden, Department of Medical Humanities, UMC Utrecht, for their helpful feedback on an earlier version of the manuscript. This work has been supported by a grant from The Netherlands Organisation for Health Research and Development ZonMw project number 70-73000-98-086.

Author information

Affiliations

  1. Julius Center for Health Sciences and Primary Care, Department of Medical Humanities, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands

    • Sarah N. Boers
    •  & Annelien L. Bredenoord

Authors

  1. Search for Sarah N. Boers in:

  2. Search for Annelien L. Bredenoord in:

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Annelien L. Bredenoord.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41556-018-0112-5

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.