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DEVELOPMENT

Mammary lineage restriction in development

The establishment of the two distinct lineages that form the branched epithelial ductal tree of the mammary gland is a complex and essential developmental process. Two independent studies now describe the switch from multipotency to unipotency as an embryonic process and outline mechanisms of early lineage restriction.

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Fig. 1: Schematic representation of embryonic bifurcation of the mammary lineage and reprogramming of mammary epithelial cells after lineage restriction.

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Correspondence to Beatrice A. Howard.

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Bland, P., Howard, B.A. Mammary lineage restriction in development. Nat Cell Biol 20, 637–639 (2018). https://doi.org/10.1038/s41556-018-0111-6

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