Multiple clones of cancer cells co-exist within a tumour, and yet it is not clear when these subclones arise and how they contribute to tumour progression. A multicolour clonal tracing study now shows that benign skin tumours are mostly monoclonal while the more advanced lesions are composed of multiple intermixed subclones.
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Janiszewska, M., Polyak, K. A confetti trail of tumour evolution. Nat Cell Biol 20, 639–641 (2018). https://doi.org/10.1038/s41556-018-0110-7