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STEM CELLS

Brd4-independence in ground state pluripotency

Brd4, a reader of histone acetylation, is a transcriptional co-activator implicated in the maintenance of embryonic stem cells (ESCs). A study now shows that Brd4 is dispensable in mouse ESCs maintained in ground state pluripotency, and that cooperative activity of Tet1/2 and ESC-specific transcription factors compensates for its loss.

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Fig. 1: Brd4 independence in ground state pluripotency.

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Correspondence to Hendrik G. Stunnenberg.

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Atlasi, Y., Stunnenberg, H.G. Brd4-independence in ground state pluripotency. Nat Cell Biol 20, 513–515 (2018). https://doi.org/10.1038/s41556-018-0099-y

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