Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CANCER

MYC sets a tumour-stroma metabolic loop

How the metabolic crosstalk between cancer and stromal cells affects tumour growth is incompletely defined. MYC-activated cancer cells are now shown to secrete exosomal miR-105, which fuels tumour growth by inducing a MYC-dependent metabolic programme in cancer-associated fibroblasts.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Schematic model of the MYC-dependent metabolic rewiring of CAFs and tumour cells through exosomal miR-105.

References

  1. 1.

    Bissell, M. J., Radisky, D. C., Rizki, A., Weaver, V. M. & Petersen, O. W. Differentiation. 70, 537–546 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Tao, L., Huang, G., Song, H., Chen, Y. & Chen, L. Oncology Lett 14, 2611–2620 (2017).

    Article  Google Scholar 

  3. 3.

    Olumi, A. F. et al. Cancer Res. 59, 5002–5011 (1999).

    CAS  PubMed  Google Scholar 

  4. 4.

    Kalluri, R. & Zeisberg, M. Nature Rev. Cancer 6, 392–401 (2006).

    CAS  Article  Google Scholar 

  5. 5.

    Orimo, A. et al. Cell 121, 335–348 (2005).

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Chuaysri, C. et al. Oncology Rep 21, 957–969 (2009).

    CAS  Google Scholar 

  7. 7.

    Martinez-Outschoorn, U. E., Lisanti, M. P. & Sotgia, F. Semin. Cancer Biol. 25, 47–60 (2014).

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Whitaker-Menezes, D. et al. Cell Cycle 10, 1772–1783 (2011).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Kalluri, R. J. Clin. Invest 126, 1208–1215 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Paggetti, J. et al. Blood 126, 1106–1117 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Fong, M. Y. et al. Nat. Cell Biol. 17, 183–194 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Zhao, H. et al. eLife 5, e10250 (2016).

    PubMed  PubMed Central  Google Scholar 

  13. 13.

    Yan, W. et al. Nat. Cell Biol.. https://doi.org/10.1038/s41556-018-0083-6 (2018).

    PubMed  Google Scholar 

  14. 14.

    Dang, C. V. Cold Spring Harb Perspect Med. 3, a014217 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Rasanen, K. & Vaheri, A. Exp. Cell Res. 316, 2713–2722 (2010).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the Cancer Research Institute CLIP grant.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hilary A. Coller.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Coller, H.A. MYC sets a tumour-stroma metabolic loop. Nat Cell Biol 20, 506–507 (2018). https://doi.org/10.1038/s41556-018-0096-1

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing