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MYC sets a tumour-stroma metabolic loop

Nature Cell Biology volume 20, pages 506–507 (2018)Cite this article

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How the metabolic crosstalk between cancer and stromal cells affects tumour growth is incompletely defined. MYC-activated cancer cells are now shown to secrete exosomal miR-105, which fuels tumour growth by inducing a MYC-dependent metabolic programme in cancer-associated fibroblasts.

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Fig. 1: Schematic model of the MYC-dependent metabolic rewiring of CAFs and tumour cells through exosomal miR-105.

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Acknowledgements

This work was supported by the Cancer Research Institute CLIP grant.

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Authors and Affiliations

  1. Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA

    Hilary A. Coller

  2. Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, CA, USA

    Hilary A. Coller

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  1. Hilary A. Coller
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Correspondence to Hilary A. Coller.

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Coller, H.A. MYC sets a tumour-stroma metabolic loop. Nat Cell Biol 20, 506–507 (2018). https://doi.org/10.1038/s41556-018-0096-1

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