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CANCER

MYC sets a tumour-stroma metabolic loop

How the metabolic crosstalk between cancer and stromal cells affects tumour growth is incompletely defined. MYC-activated cancer cells are now shown to secrete exosomal miR-105, which fuels tumour growth by inducing a MYC-dependent metabolic programme in cancer-associated fibroblasts.

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Fig. 1: Schematic model of the MYC-dependent metabolic rewiring of CAFs and tumour cells through exosomal miR-105.

References

  1. Bissell, M. J., Radisky, D. C., Rizki, A., Weaver, V. M. & Petersen, O. W. Differentiation. 70, 537–546 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tao, L., Huang, G., Song, H., Chen, Y. & Chen, L. Oncology Lett 14, 2611–2620 (2017).

    Article  Google Scholar 

  3. Olumi, A. F. et al. Cancer Res. 59, 5002–5011 (1999).

    CAS  PubMed  Google Scholar 

  4. Kalluri, R. & Zeisberg, M. Nature Rev. Cancer 6, 392–401 (2006).

    Article  CAS  Google Scholar 

  5. Orimo, A. et al. Cell 121, 335–348 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Chuaysri, C. et al. Oncology Rep 21, 957–969 (2009).

    CAS  Google Scholar 

  7. Martinez-Outschoorn, U. E., Lisanti, M. P. & Sotgia, F. Semin. Cancer Biol. 25, 47–60 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Whitaker-Menezes, D. et al. Cell Cycle 10, 1772–1783 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kalluri, R. J. Clin. Invest 126, 1208–1215 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Paggetti, J. et al. Blood 126, 1106–1117 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Fong, M. Y. et al. Nat. Cell Biol. 17, 183–194 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zhao, H. et al. eLife 5, e10250 (2016).

    PubMed  PubMed Central  Google Scholar 

  13. Yan, W. et al. Nat. Cell Biol.. https://doi.org/10.1038/s41556-018-0083-6 (2018).

    PubMed  Google Scholar 

  14. Dang, C. V. Cold Spring Harb Perspect Med. 3, a014217 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rasanen, K. & Vaheri, A. Exp. Cell Res. 316, 2713–2722 (2010).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the Cancer Research Institute CLIP grant.

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Correspondence to Hilary A. Coller.

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Coller, H.A. MYC sets a tumour-stroma metabolic loop. Nat Cell Biol 20, 506–507 (2018). https://doi.org/10.1038/s41556-018-0096-1

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