The field of autophagy research has developed rapidly since the first description of the process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is now increasingly studied at the level of organismal pathophysiology and is being connected to the medical sciences. This Historical Perspective describes a brief history of autophagy and discusses unanswered cell biological questions in the field.
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I thank Willa Yim for expert editing of this manuscript, Roland Knorr for stimulating discussions on biomolecular condensates and physical models, and all members of my laboratory for helpful suggestions. This work was supported by the Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research on Innovative Areas (Grant Numbers 25111001 and 25111005) and JST ERATO (Grant Numbers JPMJER1702).
The author declares no competing interests.
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Mizushima, N. A brief history of autophagy from cell biology to physiology and disease. Nat Cell Biol 20, 521–527 (2018). https://doi.org/10.1038/s41556-018-0092-5
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