a, Frequency with which gene whose transcriptional start site is a given distance from a TFAP2C ChIP-seq peak summit that overlaps with a region of conserved openness in naive and primed cells is positively or negatively regulated by TFAP2C. Note that for this subset of TFAP2C ChIP peaks, there is almost no predictive effect. This indicates that TFAP2C primarily mediates its regulatory role in the context of TFAP2C-dependent open chromatin sites. b, Distance of sites in a, to nearest transcription start site. Note that many are promoter associated. c-e ATAC-seq and ChIP-seq data are shown in the viscinity of c, KLF5 d, NANOG e, FGF4. The control low O2 track is the SSEA4- population, the TFAP2C−/− low O2 is the SSEA4+ population.