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Setting up the dermis for scar-free healing

Nature Cell Biology volume 20, pages 365–366 (2018)Cite this article

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During mouse back skin development, subsets of fibroblastic lineages transition from anti-fibrotic Engrailed-1 (En1) negative to pro-fibrotic En1-positive cells. Injuries of adult skin heal with scarring, whereas En1-deficient embryonic fibroblasts have the potential to promote scarless regeneration and repair.

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Fig. 1: Contribution of EPFs and ENFs to back skin development and scar formation during wound healing.

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Authors and Affiliations

  1. Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

    Masataka Yokoyama & Shahin Rafii

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  1. Masataka Yokoyama
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  2. Shahin Rafii
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Correspondence to Shahin Rafii.

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The authors declare no competing interests.

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Yokoyama, M., Rafii, S. Setting up the dermis for scar-free healing. Nat Cell Biol 20, 365–366 (2018). https://doi.org/10.1038/s41556-018-0080-9

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