Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER

CK1α promotes tumour suppressive autophagy

Nature Cell Biology volume 20, pages 369–371 (2018)Cite this article

Subjects

The phosphatase PTEN is thought to govern tumour suppression predominantly through PI-3 kinase pathway regulation. A study now shows that a non-catalytic function of CK1α outcompetes the E3 ligase NEDD4-1 to stabilize PTEN, which activates FOXO3A-dependent ATG7 expression and stimulates tumour suppressive autophagy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic representation of CK1α-elicited regulation of FOXO3A-driven tumour suppression.

References

  1. Song, M. S., Salmena, L. & Pandolfi, P. P. Nat. Rev. Mol. Cell Biol. 13, 283–296 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Rybstein, M. D., Bravo-San Pedro, J. M., Kroemer, G. & Galluzzi, L. Nat. Cell Biol. 20, 243–251 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Cai, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0065-8 (2018).

  4. Sinnberg, T. et al. Cancer Res. 70, 6999–7009 (2010).

    Article  CAS  PubMed  Google Scholar 

  5. Cheong, J. K. et al. J. Clin. Invest. 125, 1401–1418 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Richter, J. et al. BMC Cancer 18, 140 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Trotman, L. C. et al. Cell 128, 141–156 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wang, X. et al. Cell 128, 129–139 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Fouladkou, F. et al. Proc. Natl Acad. Sci. USA 105, 8585–8590 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Alimonti, A. et al. Nat. Genet. 42, 454–458 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mammucari, C. et al. Cell Metab. 6, 458–471 (2007).

    Article  CAS  PubMed  Google Scholar 

  12. Guo, J. Y. et al. Genes Dev. 27, 1447–1461 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ortega-Molina, A. et al. Cell Metab. 15, 382–394 (2012).

    Article  CAS  PubMed  Google Scholar 

  14. Garcia-Cao, I. et al. Cell 149, 49–62 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Madeo, F., Zimmermann, A., Maiuri, M. C. & Kroemer, G. J. Clin. Invest. 125, 85–93 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Cooperative Research in Biosciences, CIC bioGUNE, Bizkaia, Spain

    Ivana Hermanova & Arkaitz Carracedo

  2. Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain

    Arkaitz Carracedo

  3. Ikerbasque — Basque Foundation for Science, Bilbao, Spain

    Arkaitz Carracedo

  4. Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain

    Arkaitz Carracedo

Authors
  1. Ivana Hermanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arkaitz Carracedo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arkaitz Carracedo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hermanova, I., Carracedo, A. CK1α promotes tumour suppressive autophagy. Nat Cell Biol 20, 369–371 (2018). https://doi.org/10.1038/s41556-018-0079-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-018-0079-2

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer