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Paraspeckle factor turns TGF-β1 pro-metastatic

The roles of transforming growth factor β (TGF-β) depend on the cellular context. Paraspeckle component 1 now arises as a driver of epithelial-to-mesenchymal transition and stemness transcription factors to redirect effectors from tumour suppressive to pro-metastatic gene promoters, emerging as a contextual determinant of TGF-β function.

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References

  1. 1.

    Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Cell 139, 871–890 (2009).

  2. 2.

    Yang, J. & Weinberg, R. A. Dev. Cell 14, 818–829 (2008).

  3. 3.

    Lamouille, S., Xu, J. & Derynck, R. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014).

  4. 4.

    Peinado, H., Quintanilla, M. & Cano, A. J. Biol. Chem. 278, 21113–21123 (2003).

  5. 5.

    Thuault, S. et al. J Cell Biol 174, 175–183 (2006).

  6. 6.

    Ocana, O. H. et al. Cancer Cell 22, 709–724 (2012).

  7. 7.

    Mani, S. A. et al. Cell 133, 704–715 (2008).

  8. 8.

    Seoane, J. & Gomis, R. R. Cold Spring Harb. Perspect. Biol. 9, a022277 (2017).

  9. 9.

    Yeh, H. W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0062-y (2018).

  10. 10.

    Knott, G. J., Bond, C. S. & Fox, A. H. Nucleic Acids Res. 44, 3989–4004 (2016).

  11. 11.

    Shi, Y. & Massague, J. Cell 113, 685–700 (2003).

  12. 12.

    Brunet, A. et al. Cell 96, 857–868 (1999).

  13. 13.

    Seoane, J., Le, H. V., Shen, L., Anderson, S. A. & Massague, J. Cell 117, 211–223 (2004).

  14. 14.

    Gomis, R. R., Alarcon, C., Nadal, C., Van Poznak, C. & Massague, J. Cancer Cell 10, 203–214 (2006).

  15. 15.

    Calon, A. et al. Cancer Cell 22, 571–584 (2012).

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The authors declare no competing interests.

Correspondence to Roger R. Gomis.

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Fig. 1: PSPC1 switches TGF-β signalling towards a pro-metastatic phenotype.