The roles of transforming growth factor β (TGF-β) depend on the cellular context. Paraspeckle component 1 now arises as a driver of epithelial-to-mesenchymal transition and stemness transcription factors to redirect effectors from tumour suppressive to pro-metastatic gene promoters, emerging as a contextual determinant of TGF-β function.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Cell 139, 871–890 (2009).
Yang, J. & Weinberg, R. A. Dev. Cell 14, 818–829 (2008).
Lamouille, S., Xu, J. & Derynck, R. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014).
Peinado, H., Quintanilla, M. & Cano, A. J. Biol. Chem. 278, 21113–21123 (2003).
Thuault, S. et al. J Cell Biol 174, 175–183 (2006).
Ocana, O. H. et al. Cancer Cell 22, 709–724 (2012).
Mani, S. A. et al. Cell 133, 704–715 (2008).
Seoane, J. & Gomis, R. R. Cold Spring Harb. Perspect. Biol. 9, a022277 (2017).
Yeh, H. W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0062-y (2018).
Knott, G. J., Bond, C. S. & Fox, A. H. Nucleic Acids Res. 44, 3989–4004 (2016).
Shi, Y. & Massague, J. Cell 113, 685–700 (2003).
Brunet, A. et al. Cell 96, 857–868 (1999).
Seoane, J., Le, H. V., Shen, L., Anderson, S. A. & Massague, J. Cell 117, 211–223 (2004).
Gomis, R. R., Alarcon, C., Nadal, C., Van Poznak, C. & Massague, J. Cancer Cell 10, 203–214 (2006).
Calon, A. et al. Cancer Cell 22, 571–584 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Salvador, F., Gomis, R.R. Paraspeckle factor turns TGF-β1 pro-metastatic. Nat Cell Biol 20, 367–369 (2018). https://doi.org/10.1038/s41556-018-0078-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-018-0078-3
