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NON-CODING RNA

A lncRNA GUARDINg genome integrity

A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component of this pathway, which protects genome integrity in a pleiotropic fashion.

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Fig. 1: GUARDIN preserves genome integrity through multiple mechanisms.

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Correspondence to Maite Huarte.

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Grossi, E., Huarte, M. A lncRNA GUARDINg genome integrity. Nat Cell Biol 20, 371–372 (2018). https://doi.org/10.1038/s41556-018-0075-6

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