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RNA MODIFICATION

An additional class of m6A readers

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N6-methyladenosine (m6A) mRNA modification influences mRNA fate by stimulating recruitment of m6A reader proteins. A previously unappreciated class of m6A reader proteins is now shown to use a common RNA-binding domain and flanking regions to selectively bind m6A-containing mRNAs, increasing their translation and stability.

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Fig. 1: Three classes of m6A reader proteins.

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Correspondence to Tao Pan.

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Zhou, K.I., Pan, T. An additional class of m6A readers. Nat Cell Biol 20, 230–232 (2018). https://doi.org/10.1038/s41556-018-0046-y

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