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Illuminating MSK1’s role in tumour dormancy

Nature Cell Biology volume 20, pages 124–126 (2018)Cite this article

Intrinsic factors that regulate dormancy of disseminated tumour cells (DTCs) are predominantly unknown. Now, knockdown of MSK1 is shown to accelerate bone metastasis of luminal breast cancer cells. MSK1 acts through epigenetic mechanisms that enforce the luminal phenotype and promote steady-state maintenance of DTCs within bone.

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Fig. 1: MSK1 as a potential regulator of breast cancer population-level dormancy.

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Authors and Affiliations

  1. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Candice Alexandra Grzelak & Cyrus Michael Ghajar

  2. Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Candice Alexandra Grzelak & Cyrus Michael Ghajar

Authors
  1. Candice Alexandra Grzelak
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  2. Cyrus Michael Ghajar
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Correspondence to Cyrus Michael Ghajar.

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Grzelak, C.A., Ghajar, C.M. Illuminating MSK1’s role in tumour dormancy. Nat Cell Biol 20, 124–126 (2018). https://doi.org/10.1038/s41556-018-0035-1

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