Elucidating regulation of mitochondrial mRNA translation will improve our understanding of mitochondrial function during homeostasis and disease. Ribonuclease EXD2 is now shown to be important for mitochondrial translation and oxidative phosphorylation, and its loss enhances ROS production, slows development and extends lifespan in flies.
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Zid, B.M., Kapahi, P. Exonuclease EXD2 in mitochondrial translation. Nat Cell Biol 20, 120–122 (2018). https://doi.org/10.1038/s41556-017-0031-x
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DOI: https://doi.org/10.1038/s41556-017-0031-x
