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Mitochondrial DNA selection in human germ cells

Mitochondria contain their own circular mitochondrial DNA (mtDNA), which, over time, is subjected to mutations that may eventually result in functional defects. A study now describes genetic and metabolic selection processes during germ cell development that prevent accumulation of harmful mtDNA variants.

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Fig. 1: Mitochondrial DNA selection during development.

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Correspondence to Amander T. Clark.

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Chen, D., Clark, A.T. Mitochondrial DNA selection in human germ cells. Nat Cell Biol 20, 118–120 (2018). https://doi.org/10.1038/s41556-017-0029-4

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  • DOI: https://doi.org/10.1038/s41556-017-0029-4

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